We notify you that all tests were conducted using only human skin
and that no animal tests were conducted.
We used cadaver skin and all image scanned 
by confocal microscope system.

Cell to Cell Transmission‌ Enable Dermal Delivery

DermiShuttle is a carrier with two characteristics, designed to penetrate the SC by intercellular and the epidermis by Cell-to-Cell transmission.
‌SC is known to exist an intercellular between dead cells, but the epidermis consists of keratinocyte that creates a barrier to effective delivery.
‌By cell-to-cell transmission, DermiShuttle can deliver cargo to dermis layer.

Capability to Deliver Various Cargos

3 kDa Collagen labelled FITC

30 kDa Collagen labelled FITC

DermiShuttle technology is a platform for topical-therapeutics
We proved this through human skin models (cadaver skin), various cargo can be delivered by DermiShuttle.
Regardless of its physicochemical properties, range from small to large molecules, from hydrophobic to hydrophilic, even it is captured in particles, DermiShuttle can deliver it. We delivered all 3,000, 30,000, and 300,000 Daltons of collagen and 800,000 Daltons of hyaluronic acid to the dermis, and we could also deliver 200 nm-sized particles-the size of which hundreds of immunoglobulin (150 kDa) could be loaded-to the dermis. Moreover we prove it regardless of the hydrophilic/hydrophobic nature separately from the physical size of cargo.

300 kDa Collagen labelled FITC

Fluorescein-Liposome (200 nm)